使用纸片琼脂扩散法对硫柳汞进行定量微生物测定。
Quantitative microbiological assay of thiomersal using agar diffusion from paper discs.
作者信息
Christensen T E, Bentzon M W
出版信息
Acta Pathol Microbiol Scand B. 1979 Oct;87(5):265-9. doi: 10.1111/j.1699-0463.1979.tb02437.x.
Abstract
A quantitative assay method for determination of thiomersal in biological products is described and evaluated. A microbiological method using agar diffusion from filter paper discs is used. The advantages of the method in terms of low cost and reliability for determining the actual antimicrobial activity in the preparation are discussed. The assay method is in routine use in the production control of vaccines at our Institute.
摘要
本文描述并评估了一种测定生物制品中硫柳汞的定量分析方法。采用了一种利用滤纸片琼脂扩散的微生物学方法。讨论了该方法在成本低以及测定制剂中实际抗菌活性可靠性方面的优势。该分析方法在我们研究所的疫苗生产控制中常规使用。
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