[An immunohistochemistry study on extracellular matrix of lamina cribrosa in optic nerve head of experimental glaucoma].

OBJECTIVE

To observe the change of the macromolecular components of extracellular matrix of lamina cribrosa (LC) in experimental glaucoma.

METHODS

Immunoperoxidase (ABC) staining method was used to investigate the changes of collagen type IV and laminin in the lamina cribrosa of 9 monkey eyes with experimental glaucoma.

RESULTS

At the late stage of glaucoma, the labeling of collagen type IV and laminin were increased at pre-LC and LC area due to the accumulation of basement membrane-like materials.

CONCLUSION

The changes may be a selective response to elevated intraocular pressure. This response may alter the biochemical composition and the biomechanics of the lamina cribrosa.