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[一项关于儿童脑瘫的病例对照研究]

[A case-control study on cerebral palsy in children].

作者信息

Liu J, Li S, Lin Q, Zhao P, Zhao F, Hong S, Zheng J, Ji C, Huhe M, Li Z

机构信息

National Center for Maternal and Infant Health, Beijing Medical University, Beijing 100083.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 1999 Jul;33(4):228-30.

Abstract

OBJECTIVE

To identify the risk factors for cerebral palsy (CP) in children.

METHODS

A population-based 1:2 matched case-control study was conducted during May to June 1997 in southern Jiangsu Province of China.

RESULTS

Risk factors for CP in children could be summarized into four categories, i.e.; (1) fetal growth retardation, preterm delivery and low birth weight; (2) asphyxia at birth, intracranial hemorrhage, ischemic and hypoxic encephalopathy and hyperbilirubinemic encephalopathy; (3) delivery with vaccum suction and traumatic brain injury; and (4) other prenatal factors.

CONCLUSION

The first and second categories of risk factors correlated strongly and reproducibly with CP in children. It is emphasized that antenatal care be enforced to prevent occurrence of risk factors, such as low birth weight, etc., and the newborns with asphyxia be vigorously rescued and put under close supervision. For risk factors in the third category, the key measures should be obstetric practice and health education for the parents. But, little about the knowledge of the risk factors in the fourth category has been understood, which could be associated with those in the first two categories.

摘要

目的

确定儿童脑瘫(CP)的危险因素。

方法

1997年5月至6月在中国江苏省南部进行了一项基于人群的1:2匹配病例对照研究。

结果

儿童脑瘫的危险因素可归纳为四类,即:(1)胎儿生长迟缓、早产和低出生体重;(2)出生时窒息、颅内出血、缺血缺氧性脑病和高胆红素脑病;(3)真空吸引分娩和创伤性脑损伤;(4)其他产前因素。

结论

第一类和第二类危险因素与儿童脑瘫密切且可重复相关。强调应加强产前护理以预防低出生体重等危险因素的发生,对窒息新生儿应大力抢救并密切监护。对于第三类危险因素,关键措施应为产科实践及对家长的健康教育。但是,对第四类危险因素的了解甚少,其可能与前两类相关。

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