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[低剂量氟尿嘧啶和顺铂与低剂量优福定对复发性胃癌的长期生存的潜伏化疗——病例报告]

[Dormant chemotherapy by low-dose FP and low-dose UFT-E in recurrent gastric cancer with long-term survival--a case report].

作者信息

Tanaka Norio, Shimoda Satoshi, Takeda Nobuo, Koyama Shuntaro, Tsukahara Akihiro, Yajima Kazuto

机构信息

Dept. of Surgery, Niigata Prefectural Shibata Hospital.

出版信息

Gan To Kagaku Ryoho. 2002 Feb;29(2):297-300.

Abstract

We experienced a case of recurrent gastric cancer with a long-term survival. A 64-year-old man was admitted to the hospital for advanced gastric cancer in the upper stomach. Abdominal CT scan revealed para-aortic lymph nodal metastases. The patient underwent total gastrectomy, distal pancreatectomy, splenectomy, left adrenectomy, and left nephrectomy with D4 lymph node dissection, in what was a curability B resection. Conclusive findings were t2 (ss), n4, H0, P0, M0, and stage IVb. One year after the operation, para-aortic lymph node recurrence was evaluated. The patient was treated with low-dose cisplatin-5-FU therapy, and a partial response was observed and continued for over 2 years with an administration of UFT-E (300 mg/day). He died of repeated aggravation of para-aortic lymph node metastases 6 years and 2 months after the operation. We considered that the long-term survival of this patient was attributable to a 3-year tumor dormancy induced by low-dose cisplatin-5-FU therapy and administration of low-dose UFT.

摘要

我们遇到了一例复发性胃癌患者长期存活的病例。一名64岁男性因胃上部进展期胃癌入院。腹部CT扫描显示腹主动脉旁淋巴结转移。患者接受了全胃切除术、远端胰腺切除术、脾切除术、左肾上腺切除术和左肾切除术,并进行了D4淋巴结清扫,属于B级根治性切除。最终检查结果为t2(ss)、n4、H0、P0、M0,分期为IVb期。术后一年评估腹主动脉旁淋巴结复发情况。患者接受低剂量顺铂-5-氟尿嘧啶治疗,观察到部分缓解,并持续使用优福定(UFT-E,300毫克/天)超过2年。患者在术后6年2个月死于腹主动脉旁淋巴结转移的反复加重。我们认为该患者的长期存活归因于低剂量顺铂-5-氟尿嘧啶治疗和低剂量优福定给药诱导的3年肿瘤休眠期。

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