Mathalon Daniel H, Fedor Mark, Faustman William O, Gray Max, Askari Nusha, Ford Judith M
Department of Psychiatry, Yale University School of Medicine and Psychiatry Service and Veterans Affairs Healthcare System, West Haven, Connecticut, USA.
J Abnorm Psychol. 2002 Feb;111(1):22-41.
Error-monitoring abnormalities may underlie positive symptoms of schizophrenia. Response-synchronized event-related potentials during picture-word matching yielded error- and correct-response-related negativity (ERN, CRN) and positivity (Pe, Pc) and preresponse lateralized readiness potentials (LRP) from 18 schizophrenic patients and 18 controls. Both groups responded faster to matches than nonmatches, although patients were generally slower and made more errors to nonmatches. Compared with controls, patients, particularly with paranoid subtype, had smaller ERNs and larger CRNs, which were indistinguishable. LRPs showed evidence of more response conflict before errors than before correct responses in controls but not patients. Despite ERN/CRN abnormalities, post-error slowing and Pe were normal in patients, suggesting a dissociation of ERN and error awareness. Anterior cingulate and dorsolateral prefrontal cortical dysfunction in schizophrenia are implicated.
错误监测异常可能是精神分裂症阳性症状的潜在原因。在图片-单词匹配过程中，与反应同步的事件相关电位产生了与错误和正确反应相关的负波（ERN、CRN）和正波（Pe、Pc）以及反应前的侧化准备电位（LRP），研究对象为18名精神分裂症患者和18名对照者。两组对匹配项的反应均快于不匹配项，不过患者总体反应较慢，对不匹配项的错误更多。与对照组相比，患者，尤其是偏执型亚型患者，ERN较小而CRN较大，二者无明显差异。在对照组中，LRP显示出错误前比正确反应前有更多的反应冲突迹象，但患者未出现此现象。尽管患者存在ERN/CRN异常，但错误后反应减慢和Pe正常，这表明ERN与错误意识相互分离。精神分裂症患者的前扣带回和背外侧前额叶皮质功能障碍与此有关。
