Morris Sarah E, Yee Cindy M, Nuechterlein Keith H
Department of Psychology, University of California, Los Angeles, CA, USA.
J Abnorm Psychol. 2006 May;115(2):239-50. doi: 10.1037/0021-843X.115.2.239.
In this study, the authors sought to determine whether abnormalities exhibited by schizophrenia patients in event-related potentials associated with self-monitoring--the error-related negativity (ERN) and the correct response negativity (CRN)--persist under conditions that maximize ERN amplitude and to examine relationships between the ERN and behavior in schizophrenia. Participants performed a flanker task under 2 contingencies: one encouraging accuracy and another emphasizing speed. Compared with healthy participants, in schizophrenia patients the ERN was reduced in the accuracy condition, and the CRN was enhanced in the speed condition. The amplitude of a later ERP component, the error positivity, did not differ between groups in either task condition. Reduced self-correction and increased accuracy following errors were associated with larger ERNs in both groups. Thus, ERN generation appears to be abnormal in schizophrenia patients even under conditions demonstrated to maximize ERN amplitude; however, functional characteristics of the ERN appear to be intact.
在本研究中，作者试图确定精神分裂症患者在与自我监测相关的事件相关电位——错误相关负波（ERN）和正确反应负波（CRN）中表现出的异常在使ERN波幅最大化的条件下是否依然存在，并研究精神分裂症患者中ERN与行为之间的关系。参与者在两种情况下执行侧翼任务：一种鼓励准确性，另一种强调速度。与健康参与者相比，在准确性条件下，精神分裂症患者的ERN降低；在速度条件下，CRN增强。在两种任务条件下，两组之间后期ERP成分错误正波的波幅均无差异。两组中，自我纠正减少和错误后准确性提高均与更大的ERN相关。因此，即使在已证明可使ERN波幅最大化的条件下，精神分裂症患者的ERN产生似乎仍存在异常；然而，ERN的功能特征似乎是完整的。
