Arena Ross, Humphrey Reed
Department of Physical Therapy, New York University, New York, NY 10010, USA.
Am Heart J. 2002 Mar;143(3):427-32. doi: 10.1067/mhj.2002.119607.
Several ventilatory expired gas measures obtained during exercise testing demonstrate prognostic value in the heart failure (HF) population. Comparison of prognostic efficacy between pertinent measures is sparse.
The ability of various expressions of peak oxygen consumption (VO2), the relationship between minute ventilation (VE) and carbon dioxide production (VCO2), and the partial pressure of end-tidal carbon dioxide (P(ET)CO2) were assessed to determine which measure(s) best predicted cardiac-related hospitalization over a 1-year period in subjects diagnosed with HF.
Univariate Cox regression analysis found that several expressions of peak VO 2, VE-VCO2 relationship, and P(ET)CO2 were significant predictors of hospitalization. Multivariate Cox regression analysis revealed that the VE/VCO2 slope significantly predicted hospitalization (chi2 = 29.1, P <.00001). Peak VO 2 and P(ET)CO2 did not provide additional predictive value.
The prognostic superiority of the VE/VCO2 slope over peak VO2 may be a result of the latter measure's partial dependence on subject effort and skeletal muscle function.
运动测试期间获得的几种通气呼出气体指标在心力衰竭（HF）人群中显示出预后价值。相关指标之间预后疗效的比较较少。
评估了峰值耗氧量（VO2）的各种表达方式、分钟通气量（VE）与二氧化碳产生量（VCO2）之间的关系以及呼气末二氧化碳分压（P(ET)CO2），以确定哪些指标能最好地预测确诊为HF的受试者在1年内与心脏相关的住院情况。
单因素Cox回归分析发现，峰值VO2的几种表达方式、VE-VCO2关系和P(ET)CO2是住院的显著预测指标。多因素Cox回归分析显示，VE/VCO2斜率显著预测住院情况（χ2 = 29.1，P <.00001）。峰值VO2和P(ET)CO2没有提供额外的预测价值。
VE/VCO2斜率相对于峰值VO2的预后优势可能是由于后者部分依赖于受试者的努力和骨骼肌功能。
