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社交恐惧症患者中的酒精滥用:是否存在双相情感障碍关联?

Alcohol abuse in social phobic patients: is there a bipolar connection?

作者信息

Perugi Giulio, Frare Franco, Madaro Donato, Maremmani Icro, Akiskal Hagop S

机构信息

Department of Psychiatry, University of Pisa, Via Roma 67, 56100 Pisa, Italy.

出版信息

J Affect Disord. 2002 Feb;68(1):33-9. doi: 10.1016/s0165-0327(00)00316-5.

Abstract

BACKGROUND

Epidemiological and clinical studies have reported the frequent co-occurrence of social phobia (SP) and alcohol use disorders. Patients with SP often use alcohol to cope with the social situations they fear, and to lessen anticipatory anxiety, behavioral inhibition, and phobic avoidance. We investigated whether the presence of lifetime comorbidity with alcohol abuse was associated with significant differences as regards demographic and clinical features, family history and pattern of comorbidity in a large clinical sample of SP outpatients.

METHOD

The sample comprised 153 outpatients who met DSM-III-R diagnostic criteria for SP. Demographic, family history and course characteristics were investigated by a semi-structured interview. Social phobic symptoms and the severity of the illness have been assessed by the Liebowitz Social Anxiety Scale (LSAS) and the Liebowitz Social Phobic Disorders Rating Scale, Severity (LSPDRS). Patients completed the Hopkins Symptom Checklist (HSCL 90).

RESULTS

Thirty-four patients (22.2%) had a past or current history of alcohol abuse for at least 1 year. There were no significant differences between these patients and those without a history of alcohol abuse, as regards demographic features and lifetime comorbidity with major depression and other anxiety disorders. Bipolar disorder type II was found almost exclusively among patients with alcohol abuse, as well as family history for bipolar disorders.

LIMITATIONS

Retrospective study.

CONCLUSIONS

Our data indicate a strong relationship between bipolar II disorder and alcohol abuse comorbidity in patients with SP. The socializing and disinhibiting effect that many social phobics report might be mediated by mood elation induced by alcohol. The presence of bipolar diathesis in patients presenting with social anxiety might explain their increased susceptibility to alcohol, as they might undertake alcohol abuse as an attempt to overcome social difficulties.

摘要

背景

流行病学和临床研究报告称社交恐惧症(SP)与酒精使用障碍经常同时出现。患有社交恐惧症的患者常借助酒精来应对他们所惧怕的社交场合,减轻预期焦虑、行为抑制和恐惧回避。我们调查了在一大群社交恐惧症门诊患者中,终生合并酒精滥用是否与人口统计学和临床特征、家族病史及合并症模式存在显著差异。

方法

样本包括153名符合DSM-III-R社交恐惧症诊断标准的门诊患者。通过半结构化访谈调查人口统计学、家族病史和病程特征。社交恐惧症状及疾病严重程度通过利博维茨社交焦虑量表(LSAS)和利博维茨社交恐惧症评定量表(LSPDRS)进行评估。患者完成霍普金斯症状清单(HSCL 90)。

结果

34名患者(22.2%)有过至少1年的酒精滥用史,无论是过去还是现在。在人口统计学特征以及与重度抑郁和其他焦虑症的终生合并症方面,这些患者与无酒精滥用史的患者之间无显著差异。II型双相情感障碍几乎仅在有酒精滥用史的患者中发现,以及有双相情感障碍家族史的患者中。

局限性

回顾性研究。

结论

我们的数据表明社交恐惧症患者中II型双相情感障碍与酒精滥用合并症之间存在密切关系。许多社交恐惧症患者报告的社交和去抑制作用可能由酒精诱发的情绪高涨所介导。社交焦虑患者中双相素质的存在可能解释了他们对酒精易感性增加的原因,因为他们可能会进行酒精滥用以试图克服社交困难。

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