Cannat A, Feingold N, Caffin J C, Serre A
Ann Immunol (Paris). 1979 Sep-Oct;130C(5):675-85.
A peptidoglycan containing fraction (fraction "5") extracted from Brucella melitensis has been injected in low infra-vaccinating doses into inbred mice. The genetic control of the resulting anti-Brucella humoral response has been studied in the C57BL/6 "good responder" X DBA2 "low responder" model. The results observed in F1, F2 and reciprocal backcrosses show that the "good responder" character, although transmitted as a dominant trait, is under polygenic control and independent of H2 haplotype, Ig allotype, sexual chromosoms or the "d" coat color gene. On the other hand, the phenotypic expression of at least one of the genes involved is sex-limited and influenced by hormonal environmental factors. Moreover the expression in females of one of these sex-dependent genes is associated with the "b" coat color gene. These results are discussed in terms of their possible relevance in spontaneous or vaccinal resistance to experimental brucellosis, of the relative role of the peptidoglycan and lipoprotein moieties in fraction "5" and of the possible importance of sex-dependent and chromosome 4-linked genetic factors for B-cell functions.
从羊布鲁氏菌中提取的一种含肽聚糖的组分（组分“5”）已以低剂量亚疫苗接种量注射到近交系小鼠体内。在C57BL/6“高反应者”×DBA2“低反应者”模型中研究了由此产生的抗布鲁氏菌体液反应的遗传控制。在F1、F2和正反交回交中观察到的结果表明，“高反应者”性状虽然作为显性性状传递，但受多基因控制，且与H2单倍型、Ig同种异型、性染色体或“d”毛色基因无关。另一方面，所涉及的至少一个基因的表型表达受性别限制，并受激素环境因素影响。此外，这些性别依赖性基因之一在雌性中的表达与“b”毛色基因有关。从这些结果在对实验性布鲁氏菌病的自发或疫苗抗性中的可能相关性、组分“5”中肽聚糖和脂蛋白部分的相对作用以及性别依赖性和4号染色体连锁遗传因素对B细胞功能的可能重要性等方面进行了讨论。
