Reuber M D
Pathol Eur. 1975;10(3):241-4.
Buffalo strain male and female rats 12 weeks of age ingested 0.0114% dimethylnitrosamine in a semisynthetic diet for 12 weeks. Hepatic vein thrombosis developed along with focal fibrosis of the liver in female rats. Male rats had focal hepatic fibrosis, but not thrombosis of hepatic veins. A high incidence of hepatic vein thrombosis has been observed previously in Buffalo strain rats given carbon tetrachloride and methylcholanthrene simultaneously.
12周龄的布法罗品系雄性和雌性大鼠在半合成饲料中摄入0.0114%的二甲基亚硝胺，持续12周。雌性大鼠出现肝静脉血栓形成并伴有肝脏局灶性纤维化。雄性大鼠有局灶性肝纤维化，但无肝静脉血栓形成。此前在同时给予四氯化碳和甲基胆蒽的布法罗品系大鼠中观察到肝静脉血栓形成的高发生率。
