Choe Kwang-Min, Werner Thomas, Stöven Svenja, Hultmark Dan, Anderson Kathryn V
Molecular Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
Science. 2002 Apr 12;296(5566):359-62. doi: 10.1126/science.1070216. Epub 2002 Feb 28.
Components of microbial cell walls are potent activators of innate immune responses in animals. For example, the mammalian TLR4 signaling pathway is activated by bacterial lipopolysaccharide and is required for resistance to infection by Gram-negative bacteria. Other components of microbial surfaces, such as peptidoglycan, are also potent activators of innate immune responses, but less is known about how those components activate host defense. Here we show that a peptidoglycan recognition protein, PGRP-LC, is absolutely required for the induction of antibacterial peptide genes in response to infection in Drosophila and acts by controlling activation of the NF-kappaB family transcription factor Relish.
微生物细胞壁的成分是动物先天免疫反应的有效激活剂。例如，哺乳动物的TLR4信号通路被细菌脂多糖激活，并且是抵抗革兰氏阴性菌感染所必需的。微生物表面的其他成分，如肽聚糖，也是先天免疫反应的有效激活剂，但对于这些成分如何激活宿主防御了解较少。在这里，我们表明肽聚糖识别蛋白PGRP-LC是果蝇感染后诱导抗菌肽基因所绝对必需的，并且通过控制NF-κB家族转录因子Relish的激活来发挥作用。
