Ahonen A, Sovijärvi A R, Muittari A
Eur J Respir Dis. 1983 Apr;64(3):166-71.
Plasma glucagon levels and peak expiratory flow rates (PEF) were determined before and after treadmill exercise test in 5 atopic patients with exercise-induced asthma (EIA) and in 10 non-atopic patients with EIA, and also in 14 controls without exercise-induced bronchoconstriction. In addition, changes in plasma glucagon were determined during an allergen-inhalation challenge test in 5 asthmatics. Plasma glucagon was determined by radioimmunoassay using antiserum and 125I-labelled glucagon. Plasma glucagon level of atopic asthmatics at rest was significantly lower (P less than 0.05) than in non-atopic EIA patients. In the atopic EIA patients the plasma glucagon level increased by 41 per cent 10 minutes after exercise, whereas in the nonatopic EIA patients it decreased by about 19 per cent. In the controls there were only insignificant exercise-induced changes in the plasma glucagon level. The exercise-induced changes of the plasma glucagon in the atopic EIA patients differed significantly from those in the non-atopic EIA patients (P less than 0.05). No change in plasma glucagon was observed in five asthmatics during inhalation challenge tests with a known positive allergen. The results suggest that the rise in glucagon is a defence mechanism against exercise-induced broncho-constriction.
在5例患有运动诱发性哮喘（EIA）的特应性患者、10例患有EIA的非特应性患者以及14例无运动诱发性支气管收缩的对照者中，于跑步机运动试验前后测定血浆胰高血糖素水平和呼气峰值流速（PEF）。此外，还对5例哮喘患者在过敏原吸入激发试验期间血浆胰高血糖素的变化进行了测定。血浆胰高血糖素采用抗血清和125I标记的胰高血糖素通过放射免疫分析法测定。特应性哮喘患者静息时的血浆胰高血糖素水平显著低于（P<0.05）非特应性EIA患者。在特应性EIA患者中，运动后10分钟血浆胰高血糖素水平升高了41%，而在非特应性EIA患者中则下降了约19%。在对照者中，运动引起的血浆胰高血糖素水平变化不显著。特应性EIA患者运动诱导的血浆胰高血糖素变化与非特应性EIA患者有显著差异（P<0.05）。在5例哮喘患者使用已知阳性过敏原进行吸入激发试验期间，未观察到血浆胰高血糖素的变化。结果表明，胰高血糖素升高是针对运动诱发性支气管收缩的一种防御机制。
