儿童幽门螺杆菌感染的诊断：唾液免疫球蛋白G抗体检测与[¹³C]尿素呼气试验的比较
Diagnosis of Helicobacter pylori infection in children: comparison of a salivary immunoglobulin G antibody test with the [(13)C]urea breath test.
作者信息
Bode G, Marchildon P, Peacock J, Brenner H, Rothenbacher D
机构信息
Department of Epidemiology, University of Ulm, Ulm, Germany. guenter@
出版信息
Clin Diagn Lab Immunol. 2002 Mar;9(2):493-5. doi: 10.1128/cdli.9.2.493-495.2002.
Abstract
The prevalence of Helicobacter pylori infection in a population-based sample of 477 children (mean age plus minus standard deviation, 5.8 plus minus 0.5 years) determined by the [(13)C]urea breath test ([(13)C]UBT) was 10.7% (95% confidence interval [CI], 8.1 to 13.8%), and that determined by salivary enzyme-linked immunosorbent assay (ELISA) was 11.9% (95% CI, 9.2 to 15.2%). Compared to the [(13)C]UBT, the sensitivity and specificity of the salivary ELISA were 80.9% (95% CI, 66.3 to 90.4%) and 95.3% (95% CI, 92.7 to 97.1%), respectively.
摘要
通过[¹³C]尿素呼气试验（[¹³C]UBT）对477名儿童（平均年龄±标准差，5.8±0.5岁）的群体样本进行检测，幽门螺杆菌感染率为10.7%（95%置信区间[CI]，8.1%至13.8%）；通过唾液酶联免疫吸附测定（ELISA）得出的感染率为11.9%（95%CI，9.2%至15.2%）。与[¹³C]UBT相比，唾液ELISA的灵敏度和特异性分别为80.9%（95%CI，66.3%至90.4%）和95.3%（95%CI，92.7%至97.1%）。
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