Barrett S, Garratty E, Garratty G
Br J Haematol. 1979 Dec;43(4):575-88. doi: 10.1111/j.1365-2141.1979.tb03790.x.
Until recently, human blood neutrophils (PMN) and monocytes have been considered to be homogeneous cell populations. However, much evidence has accumulated on their functional heterogeneity. This functional heterogeneity suggests the existence of different subsets of myeloid cells analogous to T and B subsets of lymphoid cells. The goal of this study was to investigate this question of myeloid subsets by examining myeloid cells for cell surface reactivity for IgG and complement (C). Normal PMN and monocytes were examined from 60 subjects for the presence of two types of IgG-Fc receptors and two activated C components, C3b and C3d. Most PMN and monocytes showed Fc receptor activity for rabbit IgG (Fc-R). In addition, the majority of monocytes but very few PMN reacted with human IgG (anti-Rh0) coated Rh-positive erythrocytes (Fc-H). Most PMN and monocytes showed C receptor reactivity for C3b, but only a minor subpopulation of both myeloid cells had C3d receptors. These data provide evidence that human blood myeloid cells may be composed of subsets with different membrane marker reactivities.
直到最近，人类血液中的中性粒细胞（PMN）和单核细胞一直被认为是同质细胞群体。然而，关于它们功能异质性的证据已积累了很多。这种功能异质性表明存在类似于淋巴细胞T和B亚群的髓样细胞不同亚群。本研究的目的是通过检测髓样细胞的细胞表面对IgG和补体（C）的反应性来探讨髓样亚群的这个问题。从60名受试者中检测正常PMN和单核细胞，以确定两种类型的IgG-Fc受体和两种活化的C成分C3b和C3d的存在。大多数PMN和单核细胞显示出对兔IgG（Fc-R）的Fc受体活性。此外，大多数单核细胞但极少数PMN与包被人IgG（抗-Rh0）的Rh阳性红细胞（Fc-H）发生反应。大多数PMN和单核细胞显示出对C3b的C受体反应性，但只有一小部分这两种髓样细胞具有C3d受体。这些数据提供了证据，表明人类血液髓样细胞可能由具有不同膜标记反应性的亚群组成。
