[Study of platelet membrane glycoproteins and its fibrinogen binding reaction in patients with cerebral infarction and diabetes mellitus].

OBJECTIVE

To investigate the change of platelet membrane glycoproteins and its fibrinogen binding reaction in patients with cerebral infarction and type II diabetes mellitus (DM), and assess their value in the study of thrombosis and pro-thrombosis state.

METHODS

By flow cytometry, the platelet glycoprotein (GP) I b, GP II b, GP III a, GP II b- III a complex and P-selectin expression as well as fibrinogen binding reaction were analyzed in 85 patients with type II DM and 28 with cerebral infarction, and compared with that in 30 normal subjects.

RESULTS

The platelet membrane GP II b- III a complex, P-selectin expression and fibrinogen binding reaction were higher, while the platelet surface GP I b was lower in the patients with cerebral infarction and type II DM with vascular disease than those in normal group. The GP II b and GP III a were not significantly changed. There was no difference of these parameters between the type II DM without vascular disease patients and normal group.

CONCLUSION

The platelet fibrinogen binding reaction, P-selectin and GP II b- III a complex expression were increased while the GP I b decreased in patients with cerebral infarction and type II DM with vascular disease.