Crabbe J C, Alpern H P
Pharmacol Biochem Behav. 1975 Jul-Aug;3(4):647-52. doi: 10.1016/0091-3057(75)90186-0.
Male, C57BL/6J mice were given two daily trials on an appetitively-motivated successive brightness discrimination maze problem; they then received daily intraperitoneal injections of saline or d-amphetamine for 5 days. When trained again in the maze, mice in all d-amphetamine groups tended to display impaired retention: retention was significantly impaired in the 2.0 mg/kg group. Naive mice were treated exactly as were the pretrained mice except that they received no initial maze training prior to drug treatments. Mice in all naive d-amphetamine groups tended to display enhanced acquisition of the maze problem: acquisition was significantly enhanced in the 1.0 mg/kg groups. These results could not be explained as effects of d-amphetamine on attentional, motivational or other performance factors.
雄性C57BL/6J小鼠每天在一个以食欲为动机的连续亮度辨别迷宫问题上进行两次试验；然后它们连续5天每天接受腹腔注射生理盐水或d-苯丙胺。当再次在迷宫中训练时，所有d-苯丙胺组的小鼠都倾向于表现出记忆受损：2.0毫克/千克组的记忆显著受损。未训练的小鼠的处理方式与预先训练的小鼠完全相同，只是在药物处理之前没有接受初始迷宫训练。所有未训练的d-苯丙胺组的小鼠都倾向于表现出对迷宫问题的学习增强：1.0毫克/千克组的学习显著增强。这些结果不能解释为d-苯丙胺对注意力、动机或其他行为因素的影响。
