长期给予（+）-苯丙胺对大鼠迷宫行为表现的影响。
Effects of chronic administration of (+)-amphetamine on maze performance of the rat.
作者信息
Breda J B, Carlini E A, Sader N F
出版信息
Br J Pharmacol. 1969 Sep;37(1):79-86. doi: 10.1111/j.1476-5381.1969.tb09524.x.
Abstract
- The influence of (+)-amphetamine, given 1 min after each training session, on the performance of 124 rats in a Lashley III maze was measured every 48 hr.2. The first three injections of the drug significantly improved the learning ability of naive rats.3. With prolonged treatment, (+)-amphetamine strongly impaired the maze performance of these rats.4. The chronic administration of (+)-amphetamine to previously trained rats produced the same adverse effect.5. Amylobarbitone sodium given to previously trained rats 30 min before the training sessions completely blocked the adverse effect of (+)-amphetamine.6. (+)-Amphetamine did not produce impairment of performance when given chronically 30 min before training sessions, to previously trained rats.
摘要
在每次训练后1分钟给予（+）-苯丙胺，每48小时测量其对124只大鼠在拉什利Ⅲ型迷宫中表现的影响。
药物的前三次注射显著提高了未受过训练大鼠的学习能力。
随着治疗时间延长，（+）-苯丙胺严重损害了这些大鼠的迷宫表现。
对先前受过训练的大鼠长期给予（+）-苯丙胺产生了相同的不良影响。
在训练前30分钟给先前受过训练的大鼠注射戊巴比妥钠，完全阻断了（+）-苯丙胺的不良影响。
对先前受过训练的大鼠，在训练前30分钟长期给予（+）-苯丙胺时，并未产生表现受损的情况。
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