Weiner I, Feldon J
Psychopharmacology (Berl). 1986;89(3):355-9. doi: 10.1007/BF00174374.
Rats were trained in a Y maze on a two-choice simultaneous brightness discrimination with light as S+ and dark as S- (position irrelevant). Half of the animals were then switched to reversal, where the reinforcement contingencies of the original training were reversed, and the other half were switched to nonreversal, in which they learned a simultaneous right-left discrimination. Nonreversal was acquired faster than reversal in saline injected animals. The administration of 1 mg/kg d-amphetamine did not affect the acquisition of the initial brightness discrimination and of nonreversal. In contrast, the drug facilitated dramatically reversal learning. The results indicate that amphetamine enhances the attention to, or the associability of, the discriminative stimuli, leading to rapid learning to these stimuli under changed contingencies of reinforcement.
大鼠在Y型迷宫中接受双选同时亮度辨别训练，以亮作为S+，暗作为S-（位置无关）。然后，一半动物转换为反转训练，即原来训练的强化条件被反转，另一半转换为非反转训练，即它们学习同时进行左右辨别。在注射生理盐水的动物中，非反转训练比反转训练习得更快。给予1mg/kg的d-苯丙胺不影响最初亮度辨别和非反转训练的习得。相反，该药物显著促进了反转学习。结果表明，苯丙胺增强了对辨别性刺激的注意力或可关联性，导致在强化条件改变的情况下能快速学习这些刺激。
