丘脑背内侧损伤对大鼠空间辨别逆转的影响。

Effects of dorsomedial thalamic lesions on spatial discrimination reversal in the rat.

作者信息

Means L W, Hershey A E, Waterhouse G J, Lane C J

出版信息

Physiol Behav. 1975 Jun;14(6):725-9. doi: 10.1016/0031-9384(75)90064-5.

Abstract

Eight rats with lesions of the dorsomedial thalamus and 10 rats with sham operations were compared on acquisition and subsequent reversals of a spatial discrimination. The rats with thalamic damage showed greater perseveration to the incorrect choices (p less than 0.002) and made fewer reversals (p less than 0.05) and more errors (p less than 0.02) during the 100 reversal trials following initial acquisition than did the sham-operated animals. The two groups did not differ on the original acquisition.

摘要

对8只背内侧丘脑损伤的大鼠和10只假手术大鼠在空间辨别学习及随后的反转学习方面进行了比较。与假手术动物相比，丘脑损伤的大鼠在初始学习后的100次反转试验中，对错误选择的坚持性更强（p<0.002），进行的反转次数更少（p<0.05），错误更多（p<0.02）。两组在最初的学习方面没有差异。