Sawrie S M, Martin R C, Knowlton R, Faught E, Gilliam F, Kuzniecky R
Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Epilepsia. 2001 Nov;42(11):1403-7. doi: 10.1046/j.1528-1157.2001.018301.x.
To examine the relationship between hippocampal volumes, 1H magnetic resonance spectroscopy (MRS)-identified hippocampal metabolic function, and verbal memory in patients with unilateral mesial temporal lobe epilepsy (MTLE).
Hippocampal volumes, 1H MRS-derived hippocampal creatine to N-acetylaspartate (Cr/NAA), and verbal memory assessment were obtained preoperatively in 22 patients (six right, 16 left) with EEG-defined unilateral MTLE.
Left hippocampal volume correlated significantly with left hippocampal Cr/NAA (r=-0.549, p < 0.01), whereas right volume correlated significantly with right Cr/NAA (r=-0.478, p < 0.05). Verbal memory correlated significantly with left hippocampal Cr/NAA (r=-0.594, p < 0.01), but not with left hippocampal volume or right hippocampal measures.
Hippocampal volumes and 1H MRS-derived metabolite ratios are statistically related, but share only a small percentage of variance, suggesting separate but related pathophysiologic processes. Left hippocampal Cr/NAA appears to be more sensitive to verbal memory function than volumes.
研究单侧内侧颞叶癫痫（MTLE）患者海马体积、1H磁共振波谱（MRS）确定的海马代谢功能与言语记忆之间的关系。
对22例脑电图确诊为单侧MTLE的患者（6例右侧，16例左侧）术前进行海马体积、1H MRS得出的海马肌酸与N-乙酰天门冬氨酸比值（Cr/NAA）以及言语记忆评估。
左侧海马体积与左侧海马Cr/NAA显著相关（r=-0.549，p<0.01），而右侧体积与右侧Cr/NAA显著相关（r=-0.478，p<0.05）。言语记忆与左侧海马Cr/NAA显著相关（r=-0.594，p<0.01），但与左侧海马体积或右侧海马测量值无关。
海马体积与1H MRS得出的代谢物比率在统计学上相关，但仅共享一小部分方差，提示存在独立但相关的病理生理过程。左侧海马Cr/NAA似乎比体积对言语记忆功能更敏感。
