Hermann Bruce, Seidenberg Michael, Sager Mark, Carlsson Cynthia, Gidal Barry, Sheth Raj, Rutecki Paul, Asthana Sanjay
Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Epilepsia. 2008 May;49(5):731-40. doi: 10.1111/j.1528-1167.2007.01435.x. Epub 2007 Nov 21.
The purpose of this review is to examine what is known about cognitive and brain aging in elders with chronic epilepsy. We contend that much remains to be learned about the ultimate course of cognition and brain structure in persons with chronic epilepsy and concern appears warranted. Individuals with chronic epilepsy are exposed to many risk factors demonstrated to be associated with abnormal cognitive and brain aging in the general population, with many of these risk factors present in persons with chronic epilepsy as early as midlife. We suggest that a research agenda be developed to systematically identify and treat known modifiable risk factors in order to protect and promote cognitive and brain health in aging and elder persons with chronic epilepsy.
本综述的目的是研究关于慢性癫痫老年人认知和脑老化的已知情况。我们认为,关于慢性癫痫患者认知和脑结构的最终发展过程仍有许多有待了解之处,因此担忧似乎是有道理的。慢性癫痫患者暴露于许多已被证明与一般人群认知和脑异常老化相关的风险因素中,其中许多风险因素在慢性癫痫患者中年期就已存在。我们建议制定一项研究议程,以系统地识别和治疗已知的可改变风险因素,从而保护和促进慢性癫痫老年患者的认知和脑健康。