Seifert R, Bremkamp H, Junge C
Psychopharmacologia. 1975 Sep 17;43(3):285-6. doi: 10.1007/BF00429265.
The lithium blood level 24 hrs after a priming dose of lithium is a prognosticator for the therapeutic dosage required. Exactly 24 hrs following the intake of 24 mval lithium (lithium carbonate, retard form) venous blood serum is analyzed for lithium content. The necessary therapeutic dose can be inferred from a regression line which shows the negative interrelation between the 24 hr value and the therapeutic quantity of lithium necessary to achieve a blood level of 0.9 mval/1 under steady state conditions. Low 24 hr levels require high maintenance doses and vice versa. This procedure shortens the time of dose adjustment and avoids undesirable side-effects in the beginning of treatment which otherwise are not seldom the cause for the cessation of lithium intake.
锂初始剂量给药24小时后的血锂水平可作为所需治疗剂量的预测指标。在摄入24毫当量锂（缓释型碳酸锂） exactly 24小时后，分析静脉血清中的锂含量。必要的治疗剂量可从一条回归线推断得出，该回归线显示了24小时值与在稳态条件下使血锂水平达到0.9毫当量/升所需的锂治疗量之间的负相关关系。24小时水平低需要高维持剂量，反之亦然。该程序缩短了剂量调整时间，并避免了治疗开始时出现不良副作用，否则这些副作用很少是停止摄入锂的原因。
