Briken P, Nika E, Krausz M, Naber D
Zentrum für psychosoziale Medizin, Psychiatrie und Psychotherapie, Universitätsklinikum Hamburg-Eppendorf, Germany.
Fortschr Neurol Psychiatr. 2002 Mar;70(3):139-44. doi: 10.1055/s-2002-20501.
The treatment of aggressive symptoms in schizophrenic patients is a relevant clinical problem. We systematically review the efficacy of the different atypical neuroleptics on acute or persistent aggressive symptoms also regarding methodological problems. Currently typical neuroleptics are still first choice in treating acute aggressive symptoms, while risperidone and olanzapine could be alternatives. In persistent aggression clozapin shows the best specific results. Typical depot neuroleptics should be considered in cases when medication compliance is a problem.
精神分裂症患者攻击症状的治疗是一个相关的临床问题。我们系统地回顾了不同非典型抗精神病药物对急性或持续性攻击症状的疗效，也涉及方法学问题。目前，典型抗精神病药物仍是治疗急性攻击症状的首选，而利培酮和奥氮平可作为替代药物。在持续性攻击方面，氯氮平显示出最佳的特定疗效。当药物依从性存在问题时，应考虑使用典型长效抗精神病药物。
