Wiktor H, Kankofer M
I Katedry i Kliniki Ginekologii Operacyjnej Akademii Medycznej w Lublinie.
Ginekol Pol. 2001 Dec;72(12):1228-32.
The decrease of placental catalase (CAT) activity may lead to an increase of placental amounts of reactive oxygen species and can contribute to preeclampsia pathogenesis.
The aim of the study was to determine CAT activity in placentas from normal and preeclamptic pregnancies (with and without intrauterine growth restriction--IUGR).
The investigations comprised placentas obtained immediately after delivery from 22 normal pregnancies (group K), 26 pregnancies complicated by severe preeclampsia-PE without IUGR (group PE) and 23 pregnancies complicated by severe PE and IUGR (group PEI). The activity of CAT was determined using a spectrophotometric method and expressed as IU/mg protein. Comparative analysis was performed using U Mann-Whitney test.
Mean activity of CAT (MCAT) in the PEI group--0.38 +/- 0.14 (M +/- SD), was significantly lower (p < 0.001) as compared to MCAT in the group K (0.55 +/- 0.16). MCAT in the PE group (0.48 +/- 0.14) was lower than MCAT in the group K, but this difference was not statistically significant (p > 0.05). MCAT in the group PEI was significantly lower (p = 0.026) as compared to MCAT in the PE group.
The activity of CAT is decreased in placentas from pregnancies complicated by severe PE and IUGR. Obtained results may indicate that the decrease of placental CAT activity may be involved in pathogenesis of IUGR in preeclamptic pregnancies.
胎盘过氧化氢酶（CAT）活性降低可能导致胎盘活性氧含量增加，并可能促使子痫前期发病机制的形成。
本研究旨在测定正常妊娠及子痫前期妊娠（伴或不伴宫内生长受限——IUGR）胎盘的CAT活性。
研究对象包括22例正常妊娠（K组）、26例合并严重子痫前期（PE）但无IUGR的妊娠（PE组）以及23例合并严重PE及IUGR的妊娠（PEI组）产后立即获取的胎盘。采用分光光度法测定CAT活性，并以IU/mg蛋白质表示。使用U曼-惠特尼检验进行比较分析。
PEI组的CAT平均活性（MCAT）为0.38±0.14（M±SD），与K组的MCAT（0.55±0.16）相比显著降低（p<0.001）。PE组的MCAT（0.48±0.14）低于K组，但差异无统计学意义（p>0.05）。PEI组的MCAT与PE组相比显著降低（p = 0.026）。
合并严重PE及IUGR的妊娠胎盘的CAT活性降低。所得结果可能表明胎盘CAT活性降低可能参与子痫前期妊娠IUGR的发病机制。
