Wiktor H, Kankofer M
1st Chair of Obstetrics and Gynecology, University School of Medicine Lublin.
Ginekol Pol. 1998 Dec;69(12):915-8.
A deficiency in superoxide dismutase (SOD) activity in preeclamptic placentas can lead to an excess of superoxide radicals and may be responsible for the development and the severity of preeclampsia (PE).
Our studies were undertaken in order to determine placental SOD activity and to investigate their association with the development and the severity of PE.
The activity of SOD was determined using a spectrophotometric method in 22 placentas from normal term pregnancies (group K), 24 placentas from pregnancies complicated by severe PE (group PE), and 21 placentas from pregnancies complicated by severe PE and intrauterine growth retardation (IUGR) (group PEI).
Mean activity of SOD (MSOD) in 45 preeclamptic placentas 3.89 +/- 1.32 (M +/- SD) was significantly lower (P = 0.008) as compared to MSOD in the group K (6.75 +/- 1.96). MSOD in the PEI group (3.5 +/- 1.29) was significantly lower (P = 0.03) as compared to MSOD in the group K. MSOD in the PE group (4.23 +/- 1.25) was lower than MSOD in the group K, but this difference was not statistically significant (P = 0.11). MSOD in the group PEI was lower as compared to MSOD in the PE group, however this difference was not statistically significant (P = 0.23).
The studies revealed decreased SOD activity in preeclamptic placentas in comparison to normal placentas.
子痫前期胎盘中超氧化物歧化酶（SOD）活性缺乏可导致超氧自由基过量，这可能与子痫前期（PE）的发生及严重程度有关。
我们开展这些研究是为了确定胎盘SOD活性，并研究其与PE发生及严重程度的关联。
采用分光光度法测定22例足月正常妊娠胎盘（K组）、24例合并重度PE妊娠胎盘（PE组）和21例合并重度PE及胎儿宫内生长受限（IUGR）妊娠胎盘（PEI组）的SOD活性。
45例子痫前期胎盘的SOD平均活性（MSOD）为3.89±1.32（均值±标准差），与K组的MSOD（6.75±1.96）相比显著降低（P = 0.008）。PEI组的MSOD（3.5±1.29）与K组相比显著降低（P = 0.03）。PE组的MSOD（4.23±1.25）低于K组，但差异无统计学意义（P = 0.11）。PEI组的MSOD低于PE组，不过差异无统计学意义（P = 0.23）。
研究显示，与正常胎盘相比，子痫前期胎盘的SOD活性降低。
