Norman Suzanne, Tröster Alexander I, Fields Julie A, Brooks Rebecca
Department of Psychology, Xavier University, Cincinnati, Ohio 45207-6511, USA.
J Neuropsychiatry Clin Neurosci. 2002 Winter;14(1):31-6. doi: 10.1176/jnp.14.1.31.
This study compared the performance of Parkinson's disease (PD) patients with and without depression, patients with depression alone, and normal control subjects on a cognitive screening instrument, the Mattis Dementia Rating Scale (DRS) to evaluate the influences of depression and Parkinson's disease on cognition. PD affects overall level of cognitive functioning and, to a lesser extent, DRS Initiation/Perseveration, Construction, and Attention. Diminished memory was primarily related to depression. Treatment of depression may ameliorate aspects of cognitive dysfunction in the PD patient with depression.
本研究使用马蒂斯痴呆评定量表（DRS）这一认知筛查工具，比较了伴有和不伴有抑郁的帕金森病（PD）患者、单纯抑郁患者以及正常对照受试者的表现，以评估抑郁和帕金森病对认知的影响。帕金森病会影响认知功能的整体水平，在较小程度上还会影响DRS的起始/持续、构图和注意力。记忆力减退主要与抑郁有关。对伴有抑郁的帕金森病患者而言，治疗抑郁可能会改善其认知功能障碍的某些方面。
