Département de Réadaptation, Faculté de Médecine, Université Laval, QC, Canada G1V 0A6.
Parkinsons Dis. 2012;2012:308501. doi: 10.1155/2012/308501. Epub 2012 Feb 12.
Depression in Parkinson's disease (PD) is frequently associated with executive deficits, which can influence nonliteral comprehension and lexical access. This study explores whether depressive symptoms in PD modulate verbal fluency and nonliteral language comprehension. Twelve individuals with PD without depressive symptoms, 13 with PD and depressive symptoms (PDDSs), and 13 healthy controls completed a semantic and phonemic verbal fluency task and an indirect speech acts comprehension task. All groups had the same performance in the phonemic fluency task while the PDDS group was impaired in the semantic task. For the indirect speech act comprehension task, no difference was observed between the groups. However, the PDDS group had difficulty answering direct speech act questions. As some language impairments in PD become apparent when depressive symptoms are associated with the disease, it would appear to be important to take the presence of depressive symptoms into account when evaluating language abilities in PD.
帕金森病（PD）中的抑郁症状常与执行功能缺陷相关，而后者又会影响非字面理解和词汇获取。本研究旨在探究 PD 中的抑郁症状是否会影响言语流畅性和非字面语言理解。12 名无抑郁症状的 PD 患者、13 名 PD 伴抑郁症状（PDDS）患者和 13 名健康对照者完成了语义和语音流畅性任务及间接言语行为理解任务。所有组在语音流畅性任务中的表现相同，而 PDDS 组在语义任务中表现受损。对于间接言语行为理解任务，各组之间无差异。然而，PDDS 组在回答直接言语行为问题时存在困难。由于当抑郁症状与 PD 相关时，一些 PD 中的语言障碍会变得明显，因此在评估 PD 中的语言能力时，考虑到抑郁症状的存在似乎很重要。
