Mick Eric, Biederman Joseph, Prince Jefferson, Fischer Marianna J, Faraone Stephen V
Department of Psychiatry, Harvard Medical School and Pediatric Psycopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
J Dev Behav Pediatr. 2002 Feb;23(1):16-22. doi: 10.1097/00004703-200202000-00004.
The objective of the study was to evaluate an association between low birth weight (LBW) and attention-deficit hyperactivity disorder (ADHD) attending to potential family-genetic and environmental confounders. We examined 252 ADHD cases (boys and girls) and 231 non-ADHD controls and their parents. All subjects were extensively assessed with structured diagnostic interviews, cognitive assessments, and structured interviews of prenatal, infancy, and delivery complications. ADHD cases were three times more likely to have been born LBW than were non-ADHD controls, after attending to potential confounders such as prenatal exposure to alcohol and cigarettes, parental ADHD, social class, and comorbid disruptive behavior disorders in parents and offspring. If this association was causal, 13.8% of all ADHD cases could be attributed to LBW. These results converge with prior studies documenting similar associations and indicate that LBW is an independent risk factor for ADHD. Children with LBW, however, make up a relatively small proportion of children with ADHD.
该研究的目的是评估低出生体重（LBW）与注意缺陷多动障碍（ADHD）之间的关联，并关注潜在的家庭遗传和环境混杂因素。我们检查了252例ADHD病例（男孩和女孩）以及231名非ADHD对照者及其父母。所有受试者都通过结构化诊断访谈、认知评估以及产前、婴儿期和分娩并发症的结构化访谈进行了广泛评估。在考虑了潜在的混杂因素，如产前接触酒精和香烟、父母患ADHD、社会阶层以及父母和后代共患的破坏性行为障碍后，ADHD病例出生时低体重的可能性是非ADHD对照者的三倍。如果这种关联是因果关系，那么所有ADHD病例中有13.8%可归因于低出生体重。这些结果与先前记录类似关联的研究结果一致，表明低出生体重是ADHD的一个独立危险因素。然而，低出生体重儿童在ADHD儿童中所占比例相对较小。
