Helpap Burkhard, Klöppel Günter
Department of Pathology, Academic Hospital of the University of Freiburg, Postfach 720, 78207 Singen, Germany.
Virchows Arch. 2002 Mar;440(3):241-8. doi: 10.1007/s00428-001-0583-8. Epub 2002 Jan 29.
This review addresses the various morphological, immunohistochemical and cell kinetic aspects of pure and mixed neuroendocrine carcinomas of the prostate and urinary bladder and of carcinomas with focal neuroendocrine differentiation. It is important that neuroendocrine tumours of the prostate and urinary bladder be clearly distinguished from their nonneuroendocrine counterparts because of differences in treatment and prognosis. In the case of high-grade neuroendocrine carcinomas, early diagnosis and initiation of appropriate chemotherapy may increase survival and potentially induce complete remission in individual cases.
本综述探讨了前列腺和膀胱的纯神经内分泌癌、混合性神经内分泌癌以及具有局灶性神经内分泌分化的癌的各种形态学、免疫组织化学和细胞动力学方面。由于治疗和预后存在差异，明确区分前列腺和膀胱的神经内分泌肿瘤与其非神经内分泌对应物非常重要。对于高级别神经内分泌癌，早期诊断并开始适当的化疗可能会提高生存率，并有可能在个别病例中诱导完全缓解。
