Song F, Whitacre C C
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, College of Medicine and Public Health, Columbus 43210, USA.
Curr Opin Investig Drugs. 2001 Oct;2(10):1382-6.
The gut-associated lymphoid tissue (GALT) maintains a balance between immunological tolerance to dietary proteins and induction of active immune responses to pathogenic microorganisms. The oral administration of soluble protein antigens induces a state of systemic immunological unresponsiveness specific to the fed protein, termed oral tolerance. The two major mechanisms to explain oral tolerance are anergy/deletion of autoreactive lymphocytes and active suppression. This review will discuss the mechanisms of therapeutic oral tolerance in relation to events occurring at the site of antigen entry.
肠道相关淋巴组织（GALT）维持着对饮食蛋白的免疫耐受与对病原微生物的主动免疫反应诱导之间的平衡。口服可溶性蛋白抗体会诱导一种针对所摄入蛋白的全身性免疫无反应状态，称为口服耐受。解释口服耐受的两个主要机制是自身反应性淋巴细胞的失能/缺失和主动抑制。本综述将讨论与抗原进入部位发生的事件相关的治疗性口服耐受机制。
