Gregory Scott R, Piccolo Nelson, Piccolo Maria T, Piccolo Monica S, Heggers John P
School of Medicine University of Texas, Medical Branch, Galveston TX, USA.
J Altern Complement Med. 2002 Feb;8(1):77-83. doi: 10.1089/107555302753507203.
Propolis, a naturopathic substance derived from bees wax extract, has recently been praised for its antimicrobial, anti-inflammatory, and cicatrization-enhancing properties.
In our study, we compare these properties in a high-grade Brazilian propolis skin cream directly with silver sulfadiazene (SSD) in the treatment of minor burns (superficial second degree) in the ambulatory care setting (less than 20% total body surface area burned).
SETTINGS/LOCATION: The study was conducted at the burn clinic in Pronto Socorro para Queimaduras, Gioania, Brazil.
Patients were admitted to the study only if their initial presentation for burn care was within 48 hours postinjury and if bilateral wounds of similar depth and quality were present.
Patients had propolis skin cream applied to one wound and SSD applied to the other selected wound on initial presentation and underwent debridement and dressings change the following morning. Patients subsequently returned to the clinic every 3 days to have the wounds checked and dressings changed. At these check-ups, wounds were cultured for microbial growth and photographed to document inflammation and cicatrization. Patients were instructed not to disturb their wounds or change their dressings at home, thus propolis skin cream and SSD were applied to the wounds only at the specified 3-day intervals.
Our preliminary results do not show any significant difference in microbial colonization between wounds treated with SSD and propolis skin cream, however, wounds treated with propolis skin cream consistently showed less inflammation and more rapid cicatrization then those treated with SSD.
Propolis skin cream appears to have a beneficial effects on the healing of partial thickness burn wounds. If dressings had been changed more frequent the antimicrobial and wound healing effects would have been enhanced.
蜂胶是一种从蜂蜡提取物中获得的天然物质,最近因其抗菌、抗炎和促进愈合的特性而受到赞誉。
在我们的研究中,我们将一种高级巴西蜂胶护肤霜的这些特性与磺胺嘧啶银(SSD)在门诊治疗轻度烧伤(浅二度)(烧伤总面积小于20%)时进行直接比较。
该研究在巴西戈亚尼亚的Pronto Socorro para Queimaduras烧伤诊所进行。
仅当患者烧伤护理的初次就诊在受伤后48小时内且存在深度和质量相似的双侧伤口时,才被纳入研究。
患者在初次就诊时,将蜂胶护肤霜涂于一侧伤口,将SSD涂于另一侧选定伤口,并在次日进行清创和换药。患者随后每3天返回诊所检查伤口并更换敷料。在这些检查中,对伤口进行微生物生长培养并拍照,以记录炎症和愈合情况。患者被指示在家中不要触碰伤口或更换敷料,因此仅在指定的3天间隔时将蜂胶护肤霜和SSD涂于伤口。
我们的初步结果显示,用SSD和蜂胶护肤霜治疗的伤口在微生物定植方面没有显著差异,然而,用蜂胶护肤霜治疗的伤口始终显示出比用SSD治疗的伤口炎症更少且愈合更快。
蜂胶护肤霜似乎对部分厚度烧伤伤口的愈合有有益作用。如果换药更频繁,抗菌和伤口愈合效果将会增强。