硝酸银软膏对浅Ⅱ度烧伤创面影响的多中心临床研究

[Multi-center clinical study of the effect of silver nitrate ointment on the partial-thickness burn wounds].

作者信息

Liao Zhen-jiang, Huan Jing-ning, Lv Guo-zhong, Shou Yong-ming, Wang Zhi-yong

机构信息

Department of Burns, Ruijing Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200025, P. R. China.

出版信息

Zhonghua Shao Shang Za Zhi. 2006 Oct;22(5):359-61.

PMID:17285717

Abstract

OBJECTIVE

To evaluate the therapeutic effect of silver nitrate ointment on partial-thickness burn wounds, and observe its side-effects.

METHODS

Multi-center, randomized, positive drug paralleled self-controlled trial was carried out. Eighty patients with superficial partial-thickness burns, and 40 with deep-partial thickness burns were randomized into AgNO3 group and SD-Ag group according to drug topically applied to the wounds. The wound healing time, wound healing rate and bacterial culture of the wound, the effect and safety of the drug, as well as drug irritation to the wounds were studied in these two groups.

RESULTS

For the patients with superficial partial-thickness burn wounds, the wound healing time in silver nitrate group was (9.5 +/- 2.7) days, which was obviously shorter than that in SD-Ag group [(10.8 +/- 3.4) days, P <0.01]. The wound healing rate in silver nitrate group on 7 post-burn day ( PBD) was (77.9 +/- 20.5)%, which was obviously higher than that in SD-Ag group [(67.3 +/- 22.6) %, P < 0.01]. For those with deep-partial thickness burn wounds, the wound healing time in silver nitrate group was (21.5 +/- 4.8) days, which was evidently shorter than that in SD-Ag group [(23.3 +/- 6.4) days, P <0.01]. The wound healing rate in silver nitrate group on 20 PBD was (86.6 +/- 15.9)%, which was evidently higher than that in SD-Ag group [(78.5 +/- 17.7)%, P < 0.01]. Silver nitrate ointment has the same antibacterial effect as 1% SD-Ag cream, but it was less painful when applied to the open wounds.

CONCLUSION

Silver nitrate ointment is an effective and safe medicament for the clinical management of partial-thickness burn wounds.

摘要

目的

评估硝酸银软膏对浅Ⅱ度烧伤创面的治疗效果，并观察其副作用。

方法

采用多中心、随机、阳性药物平行自身对照试验。将80例浅Ⅱ度烧伤患者和40例深Ⅱ度烧伤患者按创面局部用药情况随机分为硝酸银组和磺胺嘧啶银组。观察两组患者创面愈合时间、创面愈合率、创面细菌培养情况、药物疗效及安全性，以及药物对创面的刺激性。

结果

浅Ⅱ度烧伤创面患者，硝酸银组创面愈合时间为（9.5±2.7）天，明显短于磺胺嘧啶银组[（10.8±3.4）天，P<0.01]。烧伤后7天硝酸银组创面愈合率为（77.9±20.5）%，明显高于磺胺嘧啶银组[（67.3±22.6）%，P<0.01]。深Ⅱ度烧伤创面患者，硝酸银组创面愈合时间为（21.5±4.8）天，明显短于磺胺嘧啶银组[（23.3±6.4）天，P<0.01]。烧伤后20天硝酸银组创面愈合率为（86.6±15.9）%，明显高于磺胺嘧啶银组[（78.5±17.7）%，P<0.01]。硝酸银软膏与1%磺胺嘧啶银乳膏抗菌效果相同，但用于开放性创面时疼痛较轻。