Oliver Stephen J
Laboratory of Cellular Physiology & Immunology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
Curr Rheumatol Rep. 2002 Apr;4(2):170-8. doi: 10.1007/s11926-002-0013-1.
Sarcoidosis is one in a heterogeneous family of granulomatous disorders. The clinical manifestations of sarcoidosis can vary widely, depending on the patient and the tissues involved. Recent advances in our understanding of the immunologic steps leading to granuloma formation and persistence have yet to translate into more effective care for patients with this disease. This review discusses the immunology of granuloma formation and systemic disease, the various nonpulmonary expressions of the clinical disease, and the treatment options available to the practicing physician.
结节病是一组异质性肉芽肿性疾病中的一种。结节病的临床表现差异很大，这取决于患者个体以及受累组织。我们对导致肉芽肿形成和持续存在的免疫过程的最新认识，尚未转化为对该疾病患者更有效的治疗。本文综述了肉芽肿形成及全身性疾病的免疫学、该临床疾病的各种非肺部表现，以及执业医师可采用的治疗方案。
