Rabe T, Mullholland D, van Staden J
Research Centre for Plant Growth and Development, School of Botany and Zoology, University of Natal Pietermaritzburg, Private Bag X01, 3209, Scottsville, South Africa.
J Ethnopharmacol. 2002 Apr;80(1):91-4. doi: 10.1016/s0378-8741(02)00010-7.
Vernonia colorata (Compositae) is used throughout Africa for a variety of ailments. This prompted the screening of this plant for biological activity. Previous experiments carried out in our laboratory revealed that the leaves possessed high antibacterial activity. Through conventional chromatographic techniques and bioassay-guided fractionation, the following sesquiterpene lactones were isolated and identified by spectroscopic data; vernolide (1), 11beta, 13-dihydrovernolide (2) and vernodalin (3). Only 2 is a novel compound, although its antibacterial activity is low compared to compounds 1 and 3 which had minimum inhibitory concentrations of 0.1-0.5 mg/ml against Gram-positive bacteria.
紫斑斑鸠菊（菊科）在非洲各地被用于治疗多种疾病。这促使人们对这种植物进行生物活性筛选。我们实验室之前进行的实验表明，其叶子具有很高的抗菌活性。通过传统色谱技术和生物测定导向的分级分离，分离出了以下倍半萜内酯，并通过光谱数据进行了鉴定；斑鸠菊内酯（1）、11β,13 - 二氢斑鸠菊内酯（2）和斑鸠菊苷（3）。只有2是一种新化合物，不过与对革兰氏阳性菌的最低抑菌浓度为0.1 - 0.5毫克/毫升的化合物1和3相比，其抗菌活性较低。
