Facultad de Agronomía y Zootecnia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Argentina.
Phytochemistry. 2011 Dec;72(18):2413-8. doi: 10.1016/j.phytochem.2011.09.001. Epub 2011 Sep 28.
Six compounds from the aerial parts of the Argentinean plant Hymenoxys robusta (Rusby) Parker were isolated and their structures elucidated using extensive spectroscopic analyses. These compounds comprise two inositol derivatives and four 3,4-seco-pseudoguaianolides, including vermeerin. Bioactivity assays of these compounds against bacterial and fungal pathogens showed that only vermeerin possessed antimicrobial activity specific against Staphylococcus aureus, and showed no toxicity when exposed to human-derived macrophages.
从阿根廷植物坚桦（Rusby）帕克的地上部分分离得到六种化合物，并通过广泛的光谱分析阐明了它们的结构。这些化合物包括两种肌醇衍生物和四种 3,4-裂伪愈创木烷内酯，包括vermectin。这些化合物对细菌和真菌病原体的生物活性测定表明，只有vermectin 具有针对金黄色葡萄球菌的抗菌活性，并且在暴露于人源性巨噬细胞时没有毒性。
