Imai Tadashi, Okada Hitoshi, Nanba Masanori, Kawada Kou, Kusaka Takashi, Itoh Susumu
Department of Pediatrics, Kagawa Medical University, Ikenobe 1750-1, Miki, Kitagun 761-0793, Japan.
Brain Dev. 2002 Mar;24(2):115-7. doi: 10.1016/s0387-7604(02)00015-3.
We describe a case of Henoch-Schönlein purpura (HSP) with massive intracerebral hemorrhage (ICH) in a 7-year-old-girl. A cranial CT scan revealed extensive ICH in the left parietal region and right parieto-temporal through occipital regions. At the time of ICH onset, hypertension and coagulation abnormality were not observed, but factor XIII activity was markedly reduced 9%. ICH was thought to have resulted from a marked decrease in factor XIII. Factor XIII preparation was administered immediately after the onset of ICH, and enlargement of the hemorrhagic region was not seen. The present case is the only reported case of HSP complicated by ICH in which factor XIII level was measured.
我们描述了一名7岁女童患过敏性紫癜（HSP）并伴有大量脑出血（ICH）的病例。头颅CT扫描显示左顶叶区域以及从右顶颞叶至枕叶区域有广泛的脑出血。在脑出血发作时，未观察到高血压和凝血异常，但凝血因子 XIII 活性显著降低至9%。脑出血被认为是由凝血因子 XIII 的显著减少所致。脑出血发作后立即给予了凝血因子 XIII 制剂，未发现出血区域扩大。本病例是唯一一例报道的伴有脑出血的过敏性紫癜病例，且对凝血因子 XIII 水平进行了测定。
