Tokuyama Osamu, Nakamura Yoshihiro, Muso Ayako, Fujino Yuji, Ishiko Osamu, Ogita Sachio
Department of Obstetrics and Gynecology, Osaka City University Medical School, Abeno, Osaka, Japan.
J Assist Reprod Genet. 2002 Jan;19(1):19-23. doi: 10.1023/a:1014006605859.
Evaluation of vascular endothelial growth factor (VEGF) concentrations of follicular fluid (FF) in accordance with an ovarian stimulation protocol and ovarian response.
The subjects of this study were 38 patients undergoing IVF-ET in our hospital. They were divided into three groups according to ovarian stimulation protocols; Group 1: hMG cycles (n = 19), Group 2: clomiphene citrate cycles (n = 10), Group 3: natural cycles (n = 9). They reclassified into three groups according to the number of oocytes harvested. VEGF concentration was measured in FF, employing ELISAs.
Group 1 shows lower VEGF concentrations in FF than Group 2 or Group 3. Excluding high responders from Group 1, no difference was found among these three groups. As for the reclassified groups, group of highest number of oocytes havested showed lowest VEGF concentrations in FF.
VEGF concentrations in FF might negatively correlate with the number of follicles, irrespective of the ovulation induction protocol.
根据卵巢刺激方案和卵巢反应评估卵泡液(FF)中血管内皮生长因子(VEGF)的浓度。
本研究的对象为我院38例行体外受精-胚胎移植(IVF-ET)的患者。根据卵巢刺激方案将他们分为三组;第1组:人绝经期促性腺激素(hMG)周期(n = 19),第2组:枸橼酸氯米芬周期(n = 10),第3组:自然周期(n = 9)。根据收获的卵母细胞数量将他们重新分为三组。采用酶联免疫吸附测定法(ELISAs)测量卵泡液中的VEGF浓度。
第1组卵泡液中的VEGF浓度低于第2组或第3组。将第1组中的高反应者排除后,这三组之间未发现差异。对于重新分组的情况,收获卵母细胞数量最多的组卵泡液中的VEGF浓度最低。
无论排卵诱导方案如何,卵泡液中的VEGF浓度可能与卵泡数量呈负相关。