Lee A, Christenson L K, Stouffer R L, Burry K A, Patton P E
Department of Obstetrics and Gynecology, Oregon Health Sciences University, Portland 97201, USA.
Fertil Steril. 1997 Aug;68(2):305-11. doi: 10.1016/s0015-0282(97)81520-8.
To define the relationship between serum and follicular fluid (FF) levels of vascular endothelial growth factor (VEGF), E2, and P in patients undergoing IVF; to quantify the effects of hCG on serum levels of VEGF during early pregnancy, and to report serial measurements of serum and ascites fluid levels of VEGF in a patient with severe ovarian hyperstimulation syndrome (OHSS).
Prospective observational study.
University IVF program.
PATIENTS(S): Women undergoing conventional IVF, receiving donated oocytes or spontaneously conceiving. One patient hospitalized with severe OHSS.
MAIN OUTCOME MEASURE(S): Concentrations of VEGF, E2, and P in serum, FF, or peritoneal fluid.
RESULT(S): At the time of egg retrieval, FF VEGF concentrations were positively correlated with serum and FF P concentrations and with patient age. At 11 to 14 days after ET, pregnant recipients of autologous fresh embryos had higher serum VEGF levels than both nonpregnant recipients of autologous fresh embryos and pregnant recipients of donor eggs. Elevated serum VEGF levels in a patient with severe OHSS coincided with the clinical onset and recurrence of symptoms.
CONCLUSION(S): In patients undergoing IVF, FF VEGF levels at the time of egg retrieval correlated with the degree of follicular luteinization. There is a significant ovarian contribution to circulating VEGF levels during early gestation. Elevated serum VEGF levels may be a factor in the etiology of OHSS symptoms.
确定体外受精（IVF）患者血清与卵泡液（FF）中血管内皮生长因子（VEGF）、雌二醇（E2）和孕酮（P）水平之间的关系；量化人绒毛膜促性腺激素（hCG）对妊娠早期血清VEGF水平的影响，并报告一名重度卵巢过度刺激综合征（OHSS）患者血清和腹水中VEGF水平的系列测量结果。
前瞻性观察研究。
大学IVF项目。
接受常规IVF、接受捐赠卵子或自然受孕的女性。一名因重度OHSS住院的患者。
血清、FF或腹腔液中VEGF、E2和P的浓度。
取卵时，FF中VEGF浓度与血清和FF中P浓度以及患者年龄呈正相关。胚胎移植（ET）后11至14天，自体新鲜胚胎的妊娠受者血清VEGF水平高于自体新鲜胚胎的非妊娠受者和供体卵子的妊娠受者。一名重度OHSS患者血清VEGF水平升高与临床症状的发作和复发同时出现。
在接受IVF的患者中，取卵时FF中VEGF水平与卵泡黄素化程度相关。妊娠早期循环VEGF水平有显著的卵巢来源。血清VEGF水平升高可能是OHSS症状病因的一个因素。
