Artini P G, Fasciani A, Monti M, Luisi S, D'Ambrogio G, Genazzani A R
Department of Reproductive Medicine and Child Development, University of Pisa, Italy.
Fertil Steril. 1998 Sep;70(3):560-4. doi: 10.1016/s0015-0282(98)00221-0.
To evaluate plasma and follicular fluid levels of vascular endothelial growth factor (VEGF) in women undergoing controlled ovarian hyperstimulation to establish the possible role of this growth factor as a predictive marker of ovarian hyperstimulation syndrome (OHSS).
Prospective observational study.
University hospital infertility unit.
PATIENT(S): Fifteen women at risk of OHSS and 15 controls.
INTERVENTION(S): An IM injection of hCG was administered; plasma and follicular fluid samples were collected 34-38 hours after administration of hCG.
MAIN OUTCOME MEASURE(S): VEGF levels in plasma and in follicular fluid.
RESULT(S): VEGF levels increased after hCG administration in the patients at risk of developing OHSS and in those who developed OHSS. Further, on the day of the oocyte retrieval the increase in the VEGF levels in the plasma of the patients who developed OHSS was statistically significant compared with the increase in the levels in the women who did not. On the same day, the levels of VEGF in follicular fluid were 10 times greater than those in plasma.
CONCLUSION(S): Plasma levels of VEGF peak after hCG administration and are related to the risk of developing OHSS.
评估接受控制性卵巢刺激的女性的血浆和卵泡液中血管内皮生长因子（VEGF）水平，以确定该生长因子作为卵巢过度刺激综合征（OHSS）预测标志物的可能作用。
前瞻性观察研究。
大学医院不孕不育科。
15名有OHSS风险的女性和15名对照者。
肌肉注射人绒毛膜促性腺激素（hCG）；在注射hCG后34 - 38小时采集血浆和卵泡液样本。
血浆和卵泡液中的VEGF水平。
有发生OHSS风险的患者以及发生OHSS的患者在注射hCG后VEGF水平升高。此外，在取卵当天，发生OHSS的患者血浆中VEGF水平的升高与未发生OHSS的女性相比有统计学意义。在同一天，卵泡液中VEGF水平比血浆中的高10倍。
hCG注射后血浆VEGF水平达到峰值，且与发生OHSS的风险相关。
