Hager Gordon L, Elbi Cem, Becker Matthias
Laboratory of Receptor Biology and Gene Expression, Building 41, B602, 41 Library Drive, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-5055, USA.
Curr Opin Genet Dev. 2002 Apr;12(2):137-41. doi: 10.1016/s0959-437x(02)00278-2.
The classic view of a transcriptional initiation complex is that of an assembly of factors with many protein-protein contacts, leading to a multi-component complex whose existence is a result of the stabilizing influence of the many intermolecular interactions. Recent findings from protein mobility experiments in living cells indicate that many kinds of nuclear factors move rapidly and exchange quickly with multiple targets. Two countervailing views of factor/regulatory site interactions emerge from the current literature.
转录起始复合物的经典观点认为，它是由具有众多蛋白质-蛋白质相互作用的因子组装而成，形成一个多组分复合物，其存在是多种分子间相互作用稳定影响的结果。活细胞中蛋白质流动性实验的最新发现表明，多种核因子移动迅速，并能与多个靶点快速交换。目前的文献中出现了关于因子/调控位点相互作用的两种相反观点。
