三维空间中的基因表达：细胞外基质-核连接。
Gene expression in the third dimension: the ECM-nucleus connection.
机构信息
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977R225A, Berkeley, CA 94720, USA.
出版信息
J Mammary Gland Biol Neoplasia. 2010 Mar;15(1):65-71. doi: 10.1007/s10911-010-9163-3. Epub 2010 Jan 28.
Abstract
Decades ago, we and others proposed that the dynamic interplay between a cell and its surrounding environment dictates cell phenotype and tissue structure. Whereas much has been discovered about the effects of extracellular matrix molecules on cell growth and tissue-specific gene expression, the nuclear mechanisms through which these molecules promote these physiological events remain unknown. Using mammary epithelial cells as a model, the purpose of this review is to discuss how the extracellular matrix influences nuclear structure and function in a three-dimensional context to promote epithelial morphogenesis and function in the mammary gland.
摘要
几十年前，我们和其他人提出，细胞与其周围环境的动态相互作用决定了细胞表型和组织结构。尽管已经发现了许多关于细胞生长和组织特异性基因表达的细胞外基质分子的影响，但这些分子促进这些生理事件的核机制仍不清楚。本文以乳腺上皮细胞为例，讨论了细胞外基质如何在三维环境中影响核结构和功能，以促进乳腺上皮形态发生和功能。
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