转录调控中的组蛋白甲基化

Histone methylation in transcriptional control.

作者信息

Kouzarides Tony

机构信息

Wellcome/CRC Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

出版信息

Curr Opin Genet Dev. 2002 Apr;12(2):198-209. doi: 10.1016/s0959-437x(02)00287-3.

DOI:10.1016/s0959-437x(02)00287-3

PMID:11893494

Abstract

Over the past year or so, methylation of histones has come to be recognised as a major player in the regulation of gene activity. This notion follows the discovery of lysine and arginine methyltransferases and proteins that recognise the methyl-lysine 'mark' on histones. Methylated histones have been implicated in heterochromatic repression, promoter regulation and the propagation of a repressed state via DNA methylation.

摘要

在过去一年左右的时间里，组蛋白甲基化已被公认为基因活性调控中的一个主要因素。这一观点是在发现赖氨酸和精氨酸甲基转移酶以及能够识别组蛋白上甲基化赖氨酸“标记”的蛋白质之后形成的。甲基化组蛋白与异染色质抑制、启动子调控以及通过DNA甲基化维持抑制状态有关。