de la Fuente José, Kocan Katherine M
SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ronda de Toledo s/n, 13005 Ciudad Real, Spain.
The Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Pathogens. 2022 Jul 23;11(8):827. doi: 10.3390/pathogens11080827.
Over the past two decades, RNA interference (RNAi) in ticks, in combination with omics technologies, have greatly advanced the discovery of tick gene and molecular function. While mechanisms of RNAi were initially elucidated in plants, fungi, and nematodes, the classic 2002 study by Aljamali et al. was the first to demonstrate RNAi gene silencing in ticks. Subsequently, applications of RNAi have led to the discovery of genes that impact tick function and tick-host-pathogen interactions. RNAi will continue to lead to the discovery of an array of tick genes and molecules suitable for the development of vaccines and/or pharmacologic approaches for tick control and the prevention of pathogen transmission.
在过去二十年中，蜱虫中的RNA干扰（RNAi）与组学技术相结合，极大地推动了蜱虫基因和分子功能的发现。虽然RNAi机制最初是在植物、真菌和线虫中阐明的，但Aljamali等人2002年的经典研究首次证明了蜱虫中的RNAi基因沉默。随后，RNAi的应用导致了影响蜱虫功能以及蜱虫-宿主-病原体相互作用的基因的发现。RNAi将继续推动一系列蜱虫基因和分子的发现，这些基因和分子适用于开发用于蜱虫控制和预防病原体传播的疫苗和/或药理学方法。
