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AMOP, a protein module alternatively spliced in cancer cells.

作者信息

Ciccarelli Francesca D, Doerks Tobias, Bork Peer

出版信息

Trends Biochem Sci. 2002 Mar;27(3):113-5. doi: 10.1016/s0968-0004(01)02049-7.

DOI:10.1016/s0968-0004(01)02049-7
PMID:11893501
Abstract

This article describes a new extracellular domain--AMOP, for adhesion-associated domain in MUC4 and other proteins. This domain occurs in putative cell adhesion molecules and in some splice variants of MUC4. MUC4 splice variants are overexpressed in several tumours; in particular, they are highly expressed in pancreatic carcinomas but not in normal pancreas. The presence of AMOP in cell adhesion molecules could be indicative of a role for this domain in adhesion.

摘要

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