尿苷增强了4'-去甲基表鬼臼毒素-替亚甲基-葡萄糖苷（VM 26）-环磷酰胺联合用药对皮下接种艾氏癌的化疗作用。
Uridine enhances the chemotherapeutic action of the 4'-demethylepipodophyllotoxin-thenylidene-glucoside (VM 26)-cyclophosphamide combination on i.m. implanted Ehrlich carcinoma.
作者信息
Osswald H
出版信息
Arzneimittelforschung. 1978;28(3):387-8.
PMID:580745
Abstract
The chemotherapeutic effectiveness of the simultaneously used combination of 4'-demethylepipodophyllotoxin-thenylidene-glucoside (VM 26) and cyclophosphamide was significantly enhanced by uridine in i.m. implanted Ehrlich carcinoma without increasing toxicity when uridine was applied sequentially at an interval of 20 h.
摘要
当以20小时的间隔依次应用尿苷时，在肌肉注射接种的艾氏癌中，尿苷可显著增强同时使用的4'-去甲基表鬼臼毒素-替亚甲基-葡糖苷（VM 26）与环磷酰胺联合化疗的效果，且不会增加毒性。
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