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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Beckett A H, Gibson G G

Xenobiotica. 1975 Nov;5(11):677-86. doi: 10.3109/00498257509056137.

The properties of the rabbit liver microsomal enzyme system(s) catalysing the formation of N,N-dibenzylhydroxylamine as the major metabolite of dibenzylamine have been investigated. 2. The system consists of NADPH- and NADH-dependent components which are differentiated by their different pH optima and sensitivity towards cyanide. 3. The effect of various metabolic inhibitors on the N-oxidation process in vitro are investigated. 4. The N-oxidation of the parent amine was inhibited by CO, SKF 525-A, and inhibitors known to interact with microsomal cytochrome P-450. Phenobarbitone pre-treatment stimulates further metabolism of the hydroxylamine.

对催化二苄胺形成主要代谢产物N,N-二苄基羟胺的兔肝微粒体酶系统的特性进行了研究。2. 该系统由依赖NADPH和NADH的成分组成，它们通过不同的最适pH值和对氰化物的敏感性来区分。3. 研究了各种代谢抑制剂对体外N-氧化过程的影响。4. 母体胺的N-氧化受到一氧化碳、SKF 525-A以及已知与微粒体细胞色素P-450相互作用的抑制剂的抑制。苯巴比妥预处理可刺激羟胺的进一步代谢。

Beckett A H, Gibson G G

Xenobiotica. 1975 Nov;5(11):677-86. doi: 10.3109/00498257509056137.

The properties of the rabbit liver microsomal enzyme system(s) catalysing the formation of N,N-dibenzylhydroxylamine as the major metabolite of dibenzylamine have been investigated. 2. The system consists of NADPH- and NADH-dependent components which are differentiated by their different pH optima and sensitivity towards cyanide. 3. The effect of various metabolic inhibitors on the N-oxidation process in vitro are investigated. 4. The N-oxidation of the parent amine was inhibited by CO, SKF 525-A, and inhibitors known to interact with microsomal cytochrome P-450. Phenobarbitone pre-treatment stimulates further metabolism of the hydroxylamine.

对催化二苄胺形成主要代谢产物N,N-二苄基羟胺的兔肝微粒体酶系统的特性进行了研究。2. 该系统由依赖NADPH和NADH的成分组成，它们通过不同的最适pH值和对氰化物的敏感性来区分。3. 研究了各种代谢抑制剂对体外N-氧化过程的影响。4. 母体胺的N-氧化受到一氧化碳、SKF 525-A以及已知与微粒体细胞色素P-450相互作用的抑制剂的抑制。苯巴比妥预处理可刺激羟胺的进一步代谢。