在产抗生素培养物金色链霉菌中，金霉素对自身产生金霉素抗性的诱导作用。
Induction of resistance to aurodox by aurodox in the antibiotic-producing culture, Streptomyces goldiniensis.
作者信息
Liu C M, Hermann T E, Miller P A
出版信息
J Antibiot (Tokyo). 1979 Oct;32(10):1025-32. doi: 10.7164/antibiotics.32.1025.
The sensitivity of protein and aurodox synthesis to aurodox was examined in relationship to the development of resistance to aurodix on Streptomyces goldiniensis during fermentation. It was found that the culture remains sensitive to the antibiotic as long as no aurodox is present in the medium. Resistance only develops when aurodox is present, either exogenously added or endogenously synthesized by the culture. These observations suggest that the development of resistance is an inducible process, and evidence is presented indicating that aurodox induces a specific resistance system in S. goldiniensis.
在发酵过程中，研究了金色链霉菌对奥多霉素的抗性发展与蛋白质和奥多霉素合成对奥多霉素敏感性之间的关系。结果发现，只要培养基中不存在奥多霉素，培养物就对该抗生素保持敏感。只有当存在奥多霉素时，抗性才会发展，奥多霉素可以是外源添加的，也可以是培养物内源性合成的。这些观察结果表明，抗性的发展是一个可诱导的过程，并且有证据表明奥多霉素在金色链霉菌中诱导了一种特定的抗性系统。
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