抗生素SB22484：奥多霉素类的一种新型复合物。I. 产生菌的分类学、抗生素的分离以及化学和生物学特性

Antibiotic SB22484: a novel complex of the aurodox group. I. Taxonomy of the producing organism, isolation of the antibiotics and chemical and biological characterization.

作者信息

Selva E, Beretta G, Pallanza R, Goldstein B P, Berti M, Edwards D M, Denaro M

机构信息

Merrell Dow Research Institute, Lepetit Research Center, Gerenzano (Varese), Italy.

出版信息

J Antibiot (Tokyo). 1990 Nov;43(11):1349-58. doi: 10.7164/antibiotics.43.1349.

DOI:10.7164/antibiotics.43.1349

PMID:2272911

Abstract

Antibiotic SB22484 is a novel member of the aurodox type antibiotic group produced in submerged-fermentation cultures of Streptomyces sp. NRRL 15496. The antibiotic complex is composed of two pairs of isomers with MW's of 752 and 766. The individual isomers, which were separated by preparative HPLC, equilibrate to a mixture of the isomer pair when left in aqueous solution. In vitro, SB22484 antibiotics strongly inhibited neisseriae and were also active against Streptococci, Ureaplasma urealyticum and Haemophilus influenzae.

摘要

抗生素SB22484是链霉菌属NRRL 15496在深层发酵培养中产生的奥多克斯型抗生素组的一个新成员。该抗生素复合物由两对分子量分别为752和766的异构体组成。通过制备型高效液相色谱分离得到的各个异构体，当置于水溶液中时会平衡为异构体对的混合物。在体外，SB22484抗生素强烈抑制奈瑟菌，并且对链球菌、解脲脲原体和流感嗜血杆菌也有活性。