Nindl Bradley C, Scoville Charles R, Sheehan Kathleen M, Leone Cara D, Mello Robert P
Military Performance Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760, USA.
J Appl Physiol (1985). 2002 Apr;92(4):1611-8. doi: 10.1152/japplphysiol.00892.2001.
This study evaluated the arm, trunk, and leg for fat mass, lean soft tissue mass, and bone mineral content (BMC) assessed via dual-energy X-ray absorptiometry in a group of age-matched (approximately 29 yr) men (n = 57) and women (n = 63) and determined their relationship to insulin-like growth factor I (IGF-I) and leptin. After analysis of covariance adjustment to control for differences in body mass between genders, the differences that persisted (P < or = 0.05) were for lean soft tissue mass of the arm (men: 7.1 kg vs. women: 6.4 kg) and fat mass of the leg (men: 5.3 kg vs. women: 6.8 kg). Men and women had similar (P > or = 0.05) values for fat mass of the arms and trunk and lean soft tissue mass of the legs and trunk. Serum IGF-I and insulin-like growth factor binding protein-3 correlated (P < or = 0.05) with all measures of BMC (r values ranged from 0.31 to 0.39) and some measures of lean soft tissue mass for women (r = 0.30) but not men. Leptin correlated (P < or = 0.05) similarly for measures of fat mass for both genders (r values ranging from 0.74 to 0.85) and for lean soft tissue mass of the trunk (r = 0.40) and total body (r = 0.32) for men and for the arms in women (r = 0.56). These data demonstrate that 1) the main phenotypic gender differences in body composition are that men have more of their muscle mass in their arms and women have more of their fat mass in their legs and 2) gender differences exist in the relationship between somatotrophic hormones and lean soft tissue mass.
本研究通过双能X线吸收法评估了一组年龄匹配（约29岁）的男性（n = 57）和女性（n = 63）的手臂、躯干和腿部的脂肪量、瘦软组织量和骨矿物质含量（BMC），并确定了它们与胰岛素样生长因子I（IGF-I）和瘦素的关系。在进行协方差分析以控制性别间体重差异后，持续存在的差异（P≤0.05）在于手臂的瘦软组织量（男性：7.1千克 vs. 女性：6.4千克）和腿部的脂肪量（男性：5.3千克 vs. 女性：6.8千克）。男性和女性在手臂和躯干的脂肪量以及腿部和躯干的瘦软组织量方面具有相似的值（P≥0.05）。血清IGF-I和胰岛素样生长因子结合蛋白-3与所有BMC测量值（r值范围为0.31至0.39）以及女性的一些瘦软组织量测量值（r = 0.30）相关（P≤0.05），但与男性无关。瘦素在男女两性的脂肪量测量值方面具有相似的相关性（P≤0.05）（r值范围为0.74至0.85），在男性的躯干瘦软组织量（r = 0.40）和全身瘦软组织量（r = 0.32）以及女性的手臂瘦软组织量（r = 0.56）方面也具有相关性。这些数据表明：1）身体组成的主要表型性别差异在于男性手臂的肌肉量更多，而女性腿部的脂肪量更多；2）生长激素与瘦软组织量之间的关系存在性别差异。
