Okano Hideyuki, Imai Takao, Okabe Masataka
Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
J Cell Sci. 2002 Apr 1;115(Pt 7):1355-9. doi: 10.1242/jcs.115.7.1355.
Transcription is thought to have a major role in the regulation of cell fate; the importance of translational regulation in this process has been less certain. Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved, neural RNA-binding protein Musashi, for example, controls neural cell fate. The protein functions in maintenance of the stem-cell state, differentiation, and tumorigenesis by repressing translation of particular mRNAs. In mammals it might play an important role in activating Notch signalling by repressing translation of the Notch inhibitor m-Numb.
转录被认为在细胞命运调控中起主要作用；而翻译调控在此过程中的重要性尚不太明确。最近的研究结果表明，翻译调控有助于细胞命运的决定。例如，进化上保守的神经RNA结合蛋白Musashi可控制神经细胞命运。该蛋白通过抑制特定mRNA的翻译，在维持干细胞状态、分化和肿瘤发生过程中发挥作用。在哺乳动物中，它可能通过抑制Notch抑制剂m-Numb的翻译，在激活Notch信号通路中发挥重要作用。
